Intestinal epithelial barrier function and tight junction proteins 1 with heat and exercise
نویسندگان
چکیده
5 6 7 8 1 Department of Internal Medicine, Health Sciences Center, Health Exercise & Sports Science of 9 University of New Mexico, Albuquerque, New Mexico, 87131, USA. 10 2 School of Health Sciences, Central Michigan University, Mount Pleasant, Michigan, 48859, USA. 11 3 The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, 12 University of Copenhagen, Denmark. 13 14 15 16 17 Running title: Intestinal epithelial barrier with heat and exercise 18 19 20 21
منابع مشابه
Intestinal epithelial barrier function and tight junction proteins with heat and exercise.
A single layer of enterocytes and tight junctions (intercellular multiprotein complexes) form the intestinal epithelial barrier that controls transport of molecules through transcellular and paracellular pathways. A dysfunctional or "leaky" intestinal tight junction barrier allows augmented permeation of luminal antigens, endotoxins, and bacteria into the blood stream. Various substances and co...
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Dokladny, Karol, Pope L. Moseley, and Thomas Y. Ma. Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability. Am J Physiol Gastrointest Liver Physiol 290: G204–G212, 2006; doi:10.1152/ajpgi.00401.2005.— The effects of physiologically relevant increase in temperature (37– 41°C) on intestinal epithelial tight junction (TJ) barrier ha...
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OBJECTIVE Dysfunction of the intestinal epithelial tight junction (TJ) barrier is known to have an important etiologic role in the pathophysiology of heat stroke. N-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), play a role in maintaining and protecting the TJ structure and function. This study is aimed at investigating whether n-3 P...
متن کاملPhysiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability.
The effects of physiologically relevant increase in temperature (37-41 degrees C) on intestinal epithelial tight junction (TJ) barrier have not been previously studied. Additionally, the role of heat-shock proteins (HSPs) in the regulation of intestinal TJ barrier during heat stress remains unknown. Because heat-induced disturbance of intestinal TJ barrier could lead to endotoxemia and bacteria...
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Epithelial cells line the intestinal mucosa and form an important barrier to a wide array of noxious substances in the lumen. Disruption of the barrier integrity occurs commonly in various pathologies. Long noncoding RNAs (lncRNAs) control diverse biological processes, but little is known about the role of lncRNAs in regulation of the gut permeability. Here we show that the lncRNA SPRY4-IT1 reg...
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